The standard one
Betaine anhydrous (TMG)
The usual supplement form. 'Betaine anhydrous' and 'TMG' are the same thing.
Good for: Everyday use
What variations of TMG exist?
A nutrient that helps your body turn homocysteine back into a useful amino acid. It is not the same as betaine HCl, a digestive aid. It comes in 3 forms, and they aren't all the same. Here's how they differ.
Medical Disclaimer
For education only. What's right for you depends on your health and your medications, so check with your provider before you start or switch. Book a consult
Our top pick
Every form, in plain words
The standard one
Betaine anhydrous (TMG)
The usual supplement form. 'Betaine anhydrous' and 'TMG' are the same thing.
Good for: Everyday use
The B-vitamin combo
TMG in methylation or B-vitamin formulas
Often teamed with methylfolate, B12, and B6 to lower homocysteine.
Usually skip
- Not the same thing (Betaine HCl)A different product. It adds stomach acid to help digestion and isn't used for homocysteine.
Spotting a good one on the shelf
Look for
- Look for 'Betaine anhydrous' on the label (the standard one)
Watch out for
- A label that just says 'betaine'. Check if it's betaine anhydrous (TMG) or betaine HCl.
- Methylation blends that don't list amounts
Check with your provider first if…
- You have high cholesterol. TMG can raise LDL ('bad') cholesterol at higher amounts.
- You have kidney disease
- You're pregnant or breastfeeding
- Upset stomach, nausea, or loose stools
In the Lesher Wellness store
One product in the store has TMG. Here's which form, where the label says.
Medical Disclaimer
Check with your provider before taking any of these, especially if you're pregnant or take medications.
Has betaine anhydrous (the standard one)
500 mg per serving
Ready to find the root cause?
Dr. Lesher is a Naturopathic Doctor who focuses on autoimmune and chronic conditions in women. Since 2020, she's helped hundreds of patients stop managing symptoms and start healing.