What variations of L-tryptophan exist?

An essential amino acid your body turns into serotonin and melatonin. It's used for sleep and mood. It comes in 3 forms, and they aren't all the same. Here's how they differ.

Medical Disclaimer

For education only. What's right for you depends on your health and your medications, so check with your provider before you start or switch. Book a consult 

Pick by what you want help with

Sleep & stress

Look for

The food oneL-tryptophan

The bedtime team-upSleep blends with tryptophan

Also good

Mood

Look for

One step closer5-HTP

Also good

Every form, in plain words

Also good

The food one

L-tryptophan

The form found in food. Your body turns it into 5-HTP, then serotonin.

Good for: Sleep & stress

Also good

One step closer

5-HTP

One step further along the path to serotonin.

Good for: Mood

Also good

The bedtime team-up

Sleep blends with tryptophan

Often paired with magnesium or calming herbs. Check how much tryptophan you get per serving.

Good for: Sleep & stress

Spotting a good one on the shelf

Look for

  • Look for 'L-tryptophan' on the label (the food one)

Watch out for

  • No third-party testing for purity. A contaminated batch in 1989 caused a serious illness.
  • Sleep blends that hide amounts in a proprietary mix

Check with your provider first if…

  • You take an antidepressant (such as sertraline or fluoxetine), a migraine triptan, tramadol, or another medicine that raises serotonin. Together they can cause serotonin syndrome, which can be dangerous.
  • You have bipolar disorder
  • You take sedatives or sleep medicine
  • You have liver or kidney disease
  • You're pregnant or breastfeeding
  • Drowsiness, nausea, or an upset stomach are the most common side effects
Dr. Lesher, ND

Ready to find the root cause?

Dr. Lesher is a Naturopathic Doctor who focuses on autoimmune and chronic conditions in women. Since 2020, she's helped hundreds of patients stop managing symptoms and start healing.

Book a consult now