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Phosphatidylcholine

Also called: PC, PPC (polyenylphosphatidylcholine)

The main fat-like building block of cell membranes and a natural source of choline. It's mainly used for liver support.

Medical Disclaimer

Supplements can interact with medications and aren't right for everyone, especially during pregnancy or breastfeeding, or with a chronic condition. Ask your provider before you start.

Studied for

  • Liver health, including fatty liver (some studies)
  • Getting choline from a food-like form
  • Gut lining support (early research)
  • Cell membrane support

Found naturally in

  • Egg yolks
  • Beef liver
  • Soybeans
  • Sunflower seeds
  • Meat and fish
What variations of phosphatidylcholine exist?Our top pick, what to skip, and how to read the label

Label red flags

  • 'Lecithin' sold as if it were pure phosphatidylcholine
  • The PC amount isn't listed, only the total lecithin or phospholipids

Check with a provider

  • Soy or sunflower allergy, depending on the source
  • Diarrhea, stomach upset, or a fishy body odor at higher amounts
  • Trimethylaminuria (a condition that causes a fishy body odor)
  • Taking medicines for memory loss, such as donepezil, or anticholinergic medicines
  • Pregnancy or breastfeeding. Ask which choline form and how much is right for you.

Supplements that contain it

One product in the Lesher Wellness store lists phosphatidylcholine on the label.

Dr. Lesher, ND

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Dr. Lesher is a Naturopathic Doctor who focuses on autoimmune and chronic conditions in women. Since 2020, she's helped hundreds of patients stop managing symptoms and start healing.

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