What variations of L-ornithine exist?

An amino acid your body uses to clear ammonia, a waste product of protein. It's sometimes used for fatigue, sleep, and liver support. It comes in 3 forms, and they aren't all the same. Here's how they differ.

Medical Disclaimer

For education only. What's right for you depends on your health and your medications, so check with your provider before you start or switch. Book a consult 

Our top pick

The everyday one

L-ornithine HCl

The usual supplement form.

Good for: Everyday use

  • Also consider
  • Sore muscles: the recovery one (Ornithine alpha-ketoglutarate (OKG))

Every form, in plain words

Also good

The everyday one

L-ornithine HCl

The usual supplement form.

Good for: Everyday use

Also good

The liver one

L-ornithine L-aspartate (LOLA)

The form studied for liver problems. Usually used with a doctor's care.

Also good

The recovery one

Ornithine alpha-ketoglutarate (OKG)

Studied for healing after burns or surgery. Some athletes use it too.

Good for: Sore muscles

Spotting a good one on the shelf

Look for

  • Look for 'L-ornithine HCl' on the label (the everyday one)

Watch out for

  • Muscle-building blends with many amino acids and no amounts listed

Check with your provider first if…

  • You have liver or kidney disease. Use ornithine only with a doctor's care.
  • You have gyrate atrophy, a rare inherited eye disease, where ornithine is harmful
  • You're pregnant or breastfeeding (not well studied)
  • An upset stomach or diarrhea can happen at higher doses
Dr. Lesher, ND

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