5-HTP
Also called: 5-hydroxytryptophan, Griffonia simplicifolia seed extract
A compound your body makes from tryptophan and turns into serotonin. Supplements come from the seeds of an African plant, Griffonia.
Medical Disclaimer
Supplements can interact with medications and aren't right for everyone, especially during pregnancy or breastfeeding, or with a chronic condition. Ask your provider before you start.
Studied for
- Low mood (limited evidence)
- Sleep
- Appetite and cravings (limited evidence)
- Fibromyalgia pain and sleep (limited evidence)
Found naturally in
- Not found in common foods
- Your body makes it from tryptophan
- Turkey, eggs, pumpkin seeds, and oats supply tryptophan
Label red flags
- Griffonia extract without a stated amount of 5-HTP
- No third-party testing for purity
- Blends that combine 5-HTP with St. John's wort or other herbs that raise serotonin
Check with a provider
- Taking antidepressants (SSRIs, SNRIs, MAOIs), triptans, tramadol, St. John's wort, or other medicines that raise serotonin. Together they can cause serotonin syndrome, which can be dangerous.
- Taking carbidopa for Parkinson's. The combination has caused skin thickening in rare cases.
- Bipolar disorder
- Having surgery soon. Stop it at least 2 weeks before.
- Pregnancy or breastfeeding
- Nausea is the most common side effect
Usually found in mood support formulas, sleep formulas, appetite and craving formulas. Browse the Lesher Wellness store
Parts of the body it affects
Explore what each area does and the conditions that can affect it.
Illustrations: Servier Medical Art, CC BY 4.0
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Dr. Lesher is a Naturopathic Doctor who focuses on autoimmune and chronic conditions in women. Since 2020, she's helped hundreds of patients stop managing symptoms and start healing.